Article: A Model of Synaptic Reconsolidation.
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Kastner DB; Schwalger T; Ziegler L; Gerstner W
Front Neurosci, 2016
Table 1
Model parameters .
WRITE-PROTECTED MODEL
Neuron model
Membrane Threshold Connections
V exc 0 mV
τthr
2 ms
τampa
5 ms
τadapt
250 ms
V rest -70 mV
ϑrest
-50 mV
τnmda
100 ms
g spike 10
V inh -80 mV
ϑspike
100 mV
β
0.5
w - 0.05
τm
20 ms
k w 3
Synaptic model
Synaptic state Plasticity induction
τw
200 s
a wT∕Tz 3.5
A - 2 × 10-4
k up 1 s-1
τT
200 s
a Tw 1.3
A + 5 × 10-4
k down 1/2000 s-1
τz
200 s
a zT 0.95
τx
16.8 ms
θ
0.01
k w 3
τγ
600 s
τy
33.7 ms
σ
10-2 s-1∕2
ϑγ
0.37
τtriplet
114 ms
STATE-BASED MODEL
Transition rates
α
0.017 min-1
β
0.067 min-1
τe
0.017 min-1
τl
0.01 min-1
τr
1 × 10-4 min-1
RECONSOLIDATION MODEL
Full model Reduced model
a b 1
k 0 5 × 10-4 s-1 (wp)
I 20 5.7 × 10-2 (wp)
φ
72 s
k 1 1/10,000 s-1 (wp)
0.02 s-1 (sb)
5.8 × 10-2 (sb)
ϑbig
-80 s-1
1/3,000 s-1 (sb)
m 2 × 10-3 s-1 (wp)
I 40 4.5 × 10-2
η
10 s
k 3 1/1,750 s-1 (wp)
0.25 s-1 (sb)
N A, tot 2 × 104
ω
5.4 s
1/30 s-1 (sb)
r 3 × 10-3
τA
150 s
For the reconsolidation extension different values were used for some of the parameters between the write-protected (wp) and state-based (sb) model, as indicated.
Inferred neuron-electrophysiology data values
Neuron Type
Neuron Description
Ephys Prop
Extracted Value
Standardized Value
Content Source
